Carboxytherapy originated at the Royal Spas of France in 1932 with the treatment of patients afflicted by peripheral arterial occlusive disease. In South America and Europe, carbon dioxide therapy has been applied to the treatment of stretch marks, cellulite, and hypertrophic scars with impressive results. Studies have demonstrated that carboxytherapy improves skin elasticity, improves circulation, encourages collagen repair, improves the appearance of fine lines and wrinkles, and destroys localized fatty deposits. Carbon dioxide is a natural constituent of our very being. We breathe in oxygen, and we exhale carbon dioxide. Plants take up the carbon dioxide, and in turn give us the oxygen that we need. There are no known risks associated with carboxytherapy. Carbon dioxide injection.